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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: SOCS3 inhibits the mesenchymal stromal cell secretory factor SDF-1-mediated improvement of islet function in non-obese diabetic mice

Fig. 1

Effects of SDF-1 on islet function in vitro. Islets were pre-cultured with exogenous stromal cell-derived factor-1 (SDF-1). A, B Dose-dependent protection from cytokine-induced apoptosis following 48 h pre-culture with SDF-1 and the subsequent presence of SDF-1 during the final 20 h cytokine incubation in WT islets. C Quantification of insulin staining by MetaMorph analysis in wild-type (Wt) islets. D, E Pre-culturing SOCS3 knockout (KO) islets with 10 nM SDF-1 protects from cytokine-induced apoptosis. F Quantification of insulin staining by MetaMorph analysis in SOCS3 KO islets. Magnification: × 200. *p < 0.05

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Stem Cell Research & Therapy

ISSN: 1757-6512