Fig. 4

In vivo AMD3100 administration reverses improved graft function of SDF-1 pre-cultured SOCS3-KO islets. A Blood glucose concentrations of mice transplanted with SOCS3-KO islet pre-cultured with 10 nM/L SDF-1 for 2 days, and with or without AMD3100 administration (repeated-measurement ANOVA with Bonferroni post hoc test, n = 6). B Kaplan–Meier Log-rank test of STZ-treated NOD recipients maintaining islet graft function based on blood glucose readings (< 16.7 mM/l) after transplantation with SDF-1 pre-cultured SOCS3-KO islet under the kidney capsule with or without AMD3100 administration (n = 10 per group). C Intraperitoneal glucose tolerance tests (IPGTTs) in all cured mice at 1 month after transplantation as above (repeated-measurement ANOVA with Bonferroni post hoc test, n = 3–5). D Two-way ANOVA with multiple comparisons for the area under the curve of the IPGTT. *p < 0.05