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Fig. 11 | Stem Cell Research & Therapy

Fig. 11

From: Intravenous injection of human umbilical cord-derived mesenchymal stem cells ameliorates not only blood glucose but also nephrotic complication of diabetic rats through autophagy-mediated anti-senescent mechanism

Fig. 11

Effects of MSC-CM on aging of rat podocytes in vitro by promoting autophagy. A qPCR detection of the mRNA expressions of autophagy (Beclin-1, p62, LC3B and ULK1) and senescence (p16 and p53)-related genes in rat podocytes after CQ intervention. B WB detection of the expressions of AMPK/mTOR pathway autophagy (AMPK, p-AMPK, mTOR, p-mTOR, Beclin-1, p62, LC3 and ULK1) and senescence (p16 and p53)-related proteins in rat podocytes after CQ intervention. Full-length blots of rat podocytes were presented (Additional file 2: Figs. S17–S22), respectively. Data were shown as mean ± SD, n = 3, unpaired, student's t test. *P < 0.05 and **P < 0.01 versus the normal group, #P < 0.05 and ##P < 0.01 versus the model group, △P < 0.05 and △△P < 0.01 versus the MSC-CM group

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Stem Cell Research & Therapy

ISSN: 1757-6512