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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Metformin promotes female germline stem cell proliferation by upregulating Gata-binding protein 2 with histone β-hydroxybutyrylation

Fig. 4

Histone H2BK5bhb Chip-seq and RNA-seq analysis of FGSCs treated with metformin. A Clustering of H2BK5bhb Chip-seq signals in control and treated groups. B GO annotation of differentially expressed genes with H2BK5bhb modification. C Cluster heat map of differentially expressed genes. D Volcano map of differentially expressed genes. E GO annotation analysis of RNA-seq data. F KEGG pathway analysis of RNA-seq data. C-1, C-2, C-3: control repeat-1, repeat-2, repeat-3; T-1, T-2, T-3: metformin repeat-1, repeat-2, repeat-3

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Stem Cell Research & Therapy

ISSN: 1757-6512