Fig. 1

Effects of DNCB application and MSC treatment on the development of atopic dermatitis-like symptoms in BALB/c mice. a Schematic diagram of DNCB induction and MSC treatment from day 1 to day 30. 1% DNCB was applied on days 0, 3, 6, and 9, and 0.5% DNCB solution was applied on days 12, 15, 18, 21, 24, and 27. Mice received MSCs on days 13, 17, 21, and 25. b Macroscopic views of dorsal skin appearance from representative mice of each group from day 0 to day 30. c Records of scratching frequency, dermatitis score, and body weight of mice. Two-way ANOVA with Tukey’s multiple comparison test was used to test statistical significance between the DNCB group and MSC treatment groups. ****P < 0.0001