Fig. 2

Pathological amelioration of epidermal changes by MSC treatment. a Visualization of histopathological manifestations in dorsal skin sections by hematoxylin–eosin staining. b Epidermis thickness based on tissue sections as presented in a. c Dorsal skin sections stained with toluidine blue to visualize mast cell infiltration. d Quantification of mast cell infiltration based on the number of dark violet-stained cells as presented in c. e Immunochemical staining of CD4, CD8, CD1a, CXCR3, and CCR3 of dorsal skin tissue sections. One-way ANOVA with Tukey’s multiple comparison test was used to test statistical significance of epidermal thickness and mast cell infiltration. *P < 0.05; ***P < 0.001; ****P < 0.0001