Fig. 3

Modulation of inflammatory and immune response by MSC treatment. a Immunofluorescence staining of IL-1β (red) in dorsal skin tissue sections. b Quantification of IL-1β fluorescence area of tissue sections as presented in a. c Gene expression of Il4ra and Il13ra1 in dorsal skin tissue sections and blood based on RNA seq. d Gene expression of Il17ra in dorsal skin tissue sections and blood based on RNA seq. e Gene expression of JAK-Stat pathway genes Jak1, Jak2, Jak3, Syk and Stat6 in dorsal skin tissue sections and blood based on RNA seq. f Serum levels of IgE measured by ELISA. g Gene expression of the IgE receptor gamma chain Fcer1g in dorsal skin tissue sections and blood based on RNA seq. h Gene expression of Bdkrb1, Bdkrb2 in dorsal skin, and Hrh2 in dorsal skin tissue sections and blood based on RNA seq. Data are presented in a log10 scale. Significant differences compared with DNCB group were identified by one-way ANOVA with Tukey’s multiple comparison test. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001