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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Maternal dendritic cells influence fetal allograft response following murine in-utero hematopoietic stem cell transplantation

Fig. 5

Gene expression profile and T cell (TCR) and B cell (BCR) receptor repertoire of trafficked maternal and recipient immune cells following IUT. Trafficked maternal and recipient immune cells from pIUT (DC control, n = 5), DC-depleted pIUT (n = 5), mIUT (DC control, n = 7) shared 48 genes (top panel) and up to 30% genes (bottom panel) within each IUT (a). Common gene clusters represent cell adhesion, cytokine response and immunoregulatory pathways (b). Trafficked maternal and recipient-derived BCR and TCR clonotypes (c) were similar in uninjected pups (n = 17); IUT increased TRB, TRG, reduced TRA, TRD, IGH, IGK in maternal-derived and recipient-derived clonotypes. Top 5 maternal-derived clonotypes were greatest following IUT and contracted in DC-depleted pIUT (d). Recipient-derived top 5 clonotypes were most abundant in uninjected pups (e). Large overlaps observed between DC-depleted pIUT and uninjected maternal-derived clonotypes (f) and between IUT recipients (g)

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Stem Cell Research & Therapy

ISSN: 1757-6512