Skip to main content
Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Exogenous melatonin ameliorates steroid-induced osteonecrosis of the femoral head by modulating ferroptosis through GDF15-mediated signaling

Fig. 6

MT suppressed MP-induced ferroptosis by increasing GDF15 expression. A Venn diagram: Gdf15 is the only gene from the intersection result. B Changes in the expression of the Gdf15 gene in 9 human cell types after high-dose MP treatment, including osteoblasts, endothelial cells, fibroblasts, myoblasts, monocytes, neutrophils, preadipocytes, and CD4 T and B cells. (The gene expression profiles of these cells were obtained from GSE112101.) C Changes in the expression of the Gdf15 gene after melatonin treatment. (The gene expression profiles were obtained from GSE183359 and GSE190135.) D Protein expression of GDF15 in BMSC treated with 100 µM MP and 10 µM MT or 100 µM MT for 48 h. (β-actin was selected as an internal reference. *p < 0.05 and **p < 0.01 compared with the 100 μM MP treatment group. Full-length blots are presented in Additional file 2: Figures S7, S8.)

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512