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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Recent advances in pre-conditioned mesenchymal stem/stromal cell (MSCs) therapy in organ failure; a comprehensive review of preclinical studies

Fig. 1

Hypoxia-inducible factor 1α (HIF-1α) signaling pathway. The figure depicts the action mechanism of HIF-1α in promoting the mesenchymal stem/stromal cells (MSCs)-mediated therapeutic influences. Hypoxia-response element (HRE), Hypoxia-inducible factor 1β (HIF-1β), CREB binding protein (CBP), HIF-1 prolyl hydroxylase (HPH), Indoleamine 2, 3-dioxygenase (IDO), Prostaglandin E2 (PGE2), Cyclin-dependent kinase (CDK), Vascular endothelial growth factor (VEGF), Hepatocyte growth factor (HGF), Fibroblast growth factor (FGF), Transforming growth factor beta (TGFβ), BCL-2 associated agonist of cell death (Bad), TNF-stimulated gene-6 (TSG-6)

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Stem Cell Research & Therapy

ISSN: 1757-6512