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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: GABAergic neurons differentiated from BDNF- and Dlx2-modified neural stem cells restore disrupted neural circuits in brainstem stroke

Fig. 5

BDNF promoted the survival and differentiation of NSCs. The NSCs in the GFP-NSCs, BDNF-NSCs, and TrkB-KD groups were transfected with Lenti-EGFP, Lenti-BDNF, and Lenti-shTrkB, respectively. The NSCs were transplanted on Day 7 after the stroke, and the brains were harvested on Day 28 after transplantation. A Neurons were detected by anti-MAP2 (red). Astrocytes were detected by anti-GFAP (red). B Histogram shows the percentages of MAP2 + neurons and GFAP + astrocytes. C Histogram shows the survival rates of NSCs. *P < 0.05, versus GFP-NSCs, #P < 0.05, versus BDNF-NSCs. N = 6, scale bar = 15 μm

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Stem Cell Research & Therapy

ISSN: 1757-6512