Fig. 8

NSCs transplantation treated brainstem stroke. A MRI and HE staining were performed to measure and confirm the infarct volume. N = 6, scale bar = 300 μm. B The infarct volume measured by MRI and infarct size confirmed by HE staining on Day 28 after transplantation were significantly smaller in the BDNF/Dlx2 group when compared to the PBS group, GFP-NSCs group, BDNF-NSCs group, and TrKB-KD group. N = 6, *P < 0.05, versus the BDNF/Dlx2 group. (C) On Day-4, 0, Day 1, Day 3, Day 7, Day 14, and Day 28 after transplantation, the Voetsch score (above) and limb placement test (bottom) were applied to evaluate the neurological function, and the line charts showed the behavioral test scores in Sham group, PBS group, GFP-NSCs group, BDNF-NSCs group, BDNF/Dlx2 group, and TrKB-KD group. N = 6, P < 0.05