Table 3 Multipotent fetal stem cells as therapeutic tools for infertility
From: Multipotent fetal stem cells in reproductive biology research
Stem cells | Restoration strategy | Sex | References |
|---|---|---|---|
Amniotic fluid | |||
AFSCs | Human AFSCs injected into busulfan-induced POF mice restored ovarian morphology and functions | Female | [215] |
Rat AFSCs mediated therapeutic effects on busulfan-induced azoospermia in rats | Male | [234] | |
AF-MSCs | Human AF-MSCs improved ovarian function in a physiological aging mouse model | Female | [235] |
Human AF-MSCs-derived exosomes exerted positive effects on ovarian granulosa cells in a mouse POF model | Female | [171] | |
Amniotic membrane | |||
AM-MSCs | Human AM-MSCs recovered ovarian function in a chemical-induced premature ovarian aging mouse model | Female | [236] |
Ultrasound-pretreated AM-MSCs transplantation increased reproductive organ weight and improved ovarian function in POI rats | Female | [237] | |
Human AM-MSCs exerted a therapeutic activity in a natural ovarian aging mouse model (improving follicle numbers) | Female | [172] | |
Human AM-MSCs injected into tail veins improved ovarian functions in a rat POI model | Female | [238] | |
Human AM-MSCs recovered ovarian function in a mouse POF model | Female | [166] | |
Human AM-MSCs transplanted into mouse testis upon busulfan-induced toxicity restored spermatogenesis | Male | [239] | |
Tail vein or ovary injection of human AM-MSCs improved ovarian function in rats with chemotherapy-induced POI | Female | [165] | |
Human AM-MSCs facilitated injured endometrial regeneration in a rat intrauterine adhesions model | Female | [178] | |
AECs | Human AECs recovered ovarian function in a chemical-induced premature ovarian aging mouse model | Female | [236] |
Injection of human AECs and AEC-conditioned medium into mouse ovaries protected against chemotherapy-induced damage | Female | [240] | |
Human AEC-derived exosomes restored ovarian function in chemotherapy-induced POF mice by transferring microRNAs | Female | [241] | |
Wharton´s jelly | |||
WJ-MSCs | Injection of human WJ-MSCs into testis of chemically induced azoospermic mice induced murine germ cell differentiation | Male | [242] |
Human WJ-MSCs differentiated into germ-like cells upon injection into mouse seminiferous tubules | Male | [161] | |
Intraperitoneal injection of WJ-MSCs mediated therapeutic effects on oviduct function and fertility in rats with salpingitis | Female | [175] | |
Human WJ-MSCs recovered disturbed hormone secretion and folliculogenesis in a rat POF model | Female | [243] | |
Tail vein-injected human WJ-MSCs improved the reserve function of perimenopausal rat ovaries via paracrine mechanisms | Female | [162] | |
Transplantation of human WJ-MSCs in rabbits with chronic salpingitis partially restored fertility | Female | [244] | |
Human WJ-MSCs-derived exosomes improved POI related to ovarian granulosa cell apoptosis caused by cisplatin chemotherapy | Female | [245] | |
WJ-MSCs exhibited homing characteristics and migrated to injured oviducts in rabbit to promote epithelial cell growth | Female | [174] | |
In a human phase I clinical trial intrauterine injection of WJ-MSCs increased the pregnancy rate in Asherman adhesion syndromes | Female | [179] | |
Therapeutic effect of human WJ-MSCs on tubal factor infertility in a chronic salpingitis murine model | Female | [176] | |
Microvesicles derived from human WJ-MSCs mediated therapeutic effects in a mouse POF model | Female | [246] | |
Tail vein injection of human WJ-MSCs prevented chemotherapy-induced ovarian failure in rats | Female | [163] | |
WJ-MSCs regulated ovarian stromal cell differentiation via TGFβ1 and repaired ovarian function in POI rats | Female | [168] | |
Transplantation of human WJ-MSCs improved ovarian function in a rat model of autoimmune-induced POF | Female | [247] | |
Extracellular vesicles derived from human WJ-MSCs recovered fertility of premature ovarian insufficiency mice | Female | [248] | |
Tail vein-injected human WJ-MSCs repaired chemotherapy-induced POF in mice | Female | [164] | |
Protective effects of human WJ-MSC-derived conditioned medium on a cisplatin-induced ovarian injury mouse model | Female | [249] | |
Injection of human WJ-MSCs in the ovary tissue of POF rats increased the amount of ovarian follicles | Female | [250] | |
Umbilical cord blood | |||
UCB-MSCs | Injection of human UCB-MSCs into chemotherapeutic-induced azoospermic mice improved spermatogenesis | Male | [251] |
Human UCB-MSCs restored fertility in chemotherapy-induced POI mice | Female | [252] | |
Administration of human UCB-MSCs improved degenerative changes in the follicles of CTX-induced POF mice | Female | [253] | |
Placenta | |||
CP-MSCs | 3D-cultured human CP-MSC-spheroids enhanced ovarian function by inducing folliculogenesis | Female | [254] |
Transplanted human CP-MSCs restored ovarian function in chemotherapy-treated mice | Female | [255] | |
Human CP-MSCs inhibited apoptosis of granulosa cells in autoimmune POF mice | Female | [256] | |
CP-MSC-mediated antioxidant effects restored ovarian function in an ovariectomized rat model | Female | [257] | |
Human CP-MSCs stimulated ovarian function in aged rats | Female | [169] | |
EGF released from human CP-MSCs improved POI in a mouse model | Female | [170] | |
Human CP-MSCs restored ovarian function and induced ovarian folliculogenesis in ovariectomized rats | Female | [167] | |
Human CP-MSCs ameliorated chemotherapy-induced damage in mouse testis | Male | [258] | |
Vascular remodeling by human CP-MSCs restored ovarian function in an ovariectomized rat model | Female | [173] | |
CV-MSCs | EGF released from human CV-MSCs improved POI in a mouse model | Female | [170] |
Human CV-MSCs ameliorated chemotherapy-induced damage in mouse testis | Male | [258] | |