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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Adipose tissue-derived human mesenchymal stromal cells can better suppress complement lysis, engraft and inhibit acute graft-versus-host disease in mice

Fig. 3

Immunosuppressive effect of hMSCs in vitro and survival of hMSC in vivo. A The effect of DC-mediated TNFα secretion was measured by ELISA assay. The effect of hMSCs on TH1 and Th2 was determined by measuring the release of IFNγ (TH1) and, IL-4 and IL-10 (Th2) by ELISA. NK-mediated IFNγ secretion was assessed by ELISA. The proportion of Treg was examined by flow cytometry. n = 5. Quantitative analysis of the fluorescently labelled hMSCs in the B lung and liver, C spleen and colon on days 7 and 21 post-transplantation. Graphs show data of three experiments with mean + / − SEM.*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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Stem Cell Research & Therapy

ISSN: 1757-6512