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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: MSCs’ conditioned media cytokine and growth factor profiles and their impact on macrophage polarization

Fig. 3

Cytokine concentrations in UC-MSCs-CM from 2D and 3D cultures. A Bar chart of cytokine absolute concentrations. The red horizontal dashed line separates cytokines with concentrations exceeding 1 ng/ml from other cytokines. Red rectangle borders six cytokines making major contribution to the UC-MSCs cytokine profile; B heatmap of 41 cytokines in UC-MSCs-CM scaled to row z-score. Red line borders six cytokines making major contribution to the UC-MSCs cytokine profile; C pie charts showing the percentage of six prevailing cytokines in UC-MSCs-CM from 2D and 3D cultures, and bar charts showing their absolute concentrations; D box plots showing differences in concentrations of the six prevailing cytokines in UC-MSCs-CM from 2D and 3D cultures. Statistical significance was determined using Welch’s t test; *p < 0.05; **p < 0.01

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