Fig. 2
TRPA1 improved the Ca2+ handling and electrophysiological properties of mESC-CMs. A, B Representative calcium transients of KD control, TRPA1 KD, OE control, and TRPA1 OE mESC-CMs. C, D Bar graphs showing the time-to-peak, Vmax-upstroke, decay time, and Vmax-decay of calcium transients. n = 32–60 cells from at least 3 independent batches of differentiation. E, F Representative spontaneous AP tracings of KD control, TRPA1 KD, OE control, and TRPA1 OE mESC-CMs. G, H Bar graphs showing the DDR, Vmax-upstroke, MDP, and amplitude of APs. n = 11–26 cells from at least 3 independent batches of differentiation. Data were presented as mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001