Table 3 Comparison of clinical outcome on baseline and 6Â months after implantation of P-MSCs
Case | Cell dose | Walking distance | Rest pain | ABI | Vascular quality of life (questionnaire-6) | Ischemic site status | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Day 0 | Day 180 | Day 0 | Day 180 | Day 0 | Day 180 | Day 0 | Day 180 | Day 0 | Day 180 | ||
1 | Low | 400 | 2000 | 8 | 0 | Right: 1.57 | 1.56 | 12 | 24 | Toe gangrene (amputated) surgery | Well improved |
Left: 1.09 | 1.09 | ||||||||||
2 | Low | 200 | 700 | 7 | 1 | Right: 0.8 | 1.22 | 11 | 20 | Toe necrosis/history of minor amputation | Minor amputation, well improved |
Left: 0.7 | 1.21 | ||||||||||
3 | Low | N/A | N/A | 9 | 0 | 1.13 | 1.43 | 10 | 19 | Non-healing ulcers | Ulcer healing, well improved |
4 | High | 300 | 1500 | 8 | 1 | 1.25 | 1.16 | 12 | 22 | Extensive gangrene with impending amputation/history of minor amputation | Minor amputation (day 30), well improved |
5 | High | N/A | N/A | 9 | N/A | 0.78 | N/A | 9 | N/A | Extensive gangrene with impending amputation | Major amputation (day 70) |
6 | High | 10 | 10 | 9 | 2 | 0.87 | 0.92 | 9 | 20 | Extensive gangrene with impending amputation | Minor amputation (day 90), well improved |
7 | High | 0 | 100 | 8 | 2 | 1.16 | 0.8 | 11 | 19 | Extensive gangrene with impending amputation | Minor amputation (day 40), well improved |
8 | High | 200 | 1000 | 7 | 1 | 1.17 | 1.3 | 13 | 20 | Non-healing ulcer | No change |
9 | High | 250 | 1000 | 8 | 2 | 0.98 | 1.21 | 15 | 23 | Non-healing ulcers at dorsum of the foot/gangrenous toes | Ulcer healing, No change |