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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Comparison of the therapeutic effects between stem cells and exosomes in primary ovarian insufficiency: as promising as cells but different persistency and dosage

Fig. 3

Fertility was restored by MSC treatment in the POI mouse model (n = 6 per group). A Pregnancy rate comparison between healthy mice (control), untreated POI mice (POI), and MSC-treated POI mice (MSC) in the first breeding experiment. B Pregnancy rate comparison between the control group, POI group, and MSC group in the second breeding experiment. C Average number of delivered pups per litter. D Representative image of delivered pups at Day 0. E Genomic DNA PCR analysis for detecting injected cells (human MSCs) in mouse whole blood using human-specific ALU primers (n = 3 per group). F Genomic DNA PCR analysis for detecting injected cells in neonatal offspring liver tissue using human-specific ALU primers (n = 5 per group). Data are presented as the mean ± SD. (Significance level, *p < 0.05, **p < 0.005, ***p < 0.0005, ****p < 0.0001; NS: Not significant.)

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Stem Cell Research & Therapy

ISSN: 1757-6512