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Table 2 The characteristics of laboratory parameters after 2nd infusion among the survivors in each group

From: Allogenic mesenchymal stromal cells and their extracellular vesicles in COVID-19 induced ARDS: a randomized controlled trial

Variable

MSC group (n = 8)

P-valuea

MSC + EV group (n = 8)

P-valuea

Control group (n = 16)

P-valuea

Baseline

48 h after 2nd infusion

Baseline

48 h after 2nd infusion

Baseline

48 h after 2nd infusion

WBC count (× 103)

10.7 ± 4.6

10.8 ± 4.4

0.999

13.04 ± 9.9

12.68 ± 7

0.889

7.84 ± 3.06

8.8 ± 2.7

0.6

Lymphocyte (%)

10.7 ± 3.7

12.56 ± 7.05

0.612

8.17 ± 3.3

10 ± 7.2

0.999

15.8 ± 10.4

16.8 ± 13.2

0.534

Hemoglobin (mg/dl)

14.01 ± 2.2

13.72 ± 1.46

0.674

13.2 ± 3.3

12.85 ± 7

0.726

12.5 ± 2.5

12 ± 2.3

0.033

Platelet count (× 103)

255.6 ± 115

266 ± 94.8

0.499

215.9 ± 84.5

221.6 ± 126.2

0.998

288.3 ± 214.7

285.2 ± 152.9

0.625

PT (s)

12.71 ± 0.52

12.92 ± 0.62

0.610

13.52 ± 1.7

14.1 ± 1.7

0.779

13.7 ± 1.3

13.4 ± 0.9

0.859

PTT (s)

43.71 ± 12.6

35 ± 7.4

0.018

35.2 ± 8.5

32.4 ± 8.2

0.351

40.2 ± 7.4

36.9 ± 8.5

0.137

BUN (mg/dl)

38.9 ± 15

41.9 ± 19.8

0.779

33.6 ± 14.6

45.7 ± 33.3

0.128

49.2 ± 30.2

36.2 ± 16.5

0.028

Creatinine (mg/dl)

1.12 ± 0.23

1.06 ± 0.22

0.157

0.9 ± 0.2

0.9 ± 0.3

0.786

1.2 ± 0.4

0.96 ± 0.2

0.228

AST (U/L)

43.12 ± 45.9

36.12 ± 18.8

0.779

37.6 ± 7.02

27.2 ± 7.9

0.057

60.7 ± 59.5

59.6 ± 32.9

0.575

ALT (U/L)

54.7 ± 66.9

64.5 ± 59.2

0.058

46.2 ± 33.7

40.4 ± 26

0.207

57.2 ± 53.4

58.6 ± 23

0.594

Alkp (IU/L)

172.9 ± 37.5

150 ± 35.9

0.063

135.2 ± 38

127.4 ± 45.3

0.344

197 ± 63.5

219.2 ± 92.2

0.327

Bilirubin (mg/dl)

0.76 ± 0.24

0.67 ± 0.2

0.084

0.68 ± 0.3

1.03 ± 0.2

0.058

1.2 ± 1.1

1.5 ± 1.4

0.270

PH

7.4 ± 0.07

7.4 ± 0.04

0.362

7.37 ± 0.12

7.4 ± 0.07

0.916

7.4 ± 0.1

7.44 ± 0.05

0.123

PCO2 (mmHg)

49.9 ± 10.26

46.6 ± 9.2

0.263

42.8 ± 3.2

43.2 ± 7.8

0.917

48.3 ± 18.7

50.3 ± 12.7

0.441

HCO3 (meq/L)

28.8 ± 4.3

30.3 ± 3.5

0.575

30.4 ± 4.7

30.4 ± 4.9

0.753

28.2 ± 8.3

33.5 ± 5.6

0.058

O2 saturation (%)

80.8 ± 11.4

91.2 ± 7.7

0.021

75.7 ± 7

93.5 ± 5

0.027

86.7 ± 8.3

93.5 ± 3.5

0.015

Interleukin-6 (pg/ml)

209.4 ± 56.4

70.9 ± 45

0.018

207.2 ± 38.9

56.7 ± 25.6

0.028

147.5 ± 56.2

105.8 ± 76

0.138

TNF alpha (pg/ml)

28.9 ± 11.5

5.72 ± 2.7

0.018

24.2 ± 10.4

5.47 ± 26

0.038

23.9 ± 10.6

14.9 ± 6.7

0.043

IFN-gamma (pg/ml)

121.1 ± 75.8

38.6 ± 26.6

0.028

177.85 ± 53

34.2 ± 8.7

0.018

129 ± 30.9

78.2 ± 51.7

0.043

CRP (mg/L)

36.9 ± 15.36

29.7 ± 11.5

0.02

25.3 ± 10.2

15.47 ± 5

0.024

30.2 ± 14.3

27.9 ± 13.8

0.043

  1. aWilcoxon-Signed rank test
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Stem Cell Research & Therapy

ISSN: 1757-6512