Table 3 Comparing the changes of study variables between three groups
Variable | Changes in MSC group (n = 8) | Changes in MSC + EV group (n = 8) | Changes in control group (n = 16) | P-valuea |
|---|---|---|---|---|
WBC count (× 103) | − 0.03 ± 4.21 | − 0.36 ± 8.85 | 0.43 ± 2.26 | 0.726 |
Lymphocyte (%) | 1.78 ± 4.45 | 1.91 ± 6.93 | 0.97 ± 9.83 | 0.917 |
Hemoglobin (mg/dl) | − 0.28 ± 1.54 | − 0.3 ± 1.58 | − 0.51 ± 0.9 | 0.828 |
Platelet count (× 103) | 10.42 ± 68.68 | 5.75 ± 85.51 | − 3.15 ± 125.34 | 0.896 |
PT (s) | 0.21 ± 0.82 | 0.57 ± 2.71 | − 0.24 ± 1.57 | 0.927 |
PTT (s) | − 7 ± 8.56 | − 2.71 ± 8.8 | − 3.22 ± 5.56 | 0.971 |
BUN (mg/dl) | 3 ± 17.77 | 12.14 ± 19.83 | − 13 ± 25.4 | 0.019 |
Creatinine (mg/dl) | − 0.05 ± 0.09 | 0.03 ± 0.22 | − 0.2 ± 0.51 | 0.530 |
AST (U/L) | − 7 ± 32.7 | − 10.42 ± 6.67 | − 1.12 ± 45.2 | 0.132 |
ALT (U/L) | 9.75 ± 12.48 | − 5.71 ± 12.13 | 1.55 ± 49.77 | 0.138 |
Alkp (IU/L) | − 22.87 ± 23.49 | − 7.83 ± 23.6 | 22.13 ± 67.3 | 0.228 |
Bilirubin (mg/dl) | − 0.08 ± 0.12 | 0.35 ± 0.37 | 0.3 ± 1.04 | 0.037 |
PH | 0.02 ± 0.07 | 0.03 ± 0.17 | 0.04 ± 0.08 | 0.670 |
PCO2 (mmHg) | − 3.27 ± 7.73 | 0.35 ± 7.97 | 2 ± 8.48 | 0.468 |
HCO3 (meq/L) | 1.5 ± 4.92 | 0.08 ± 8.2 | 5.36 ± 6.57 | 0.259 |
O2 saturation (%) | 10.36 ± 8.63 | 17.83 ± 10.1 | 6.77 ± 6.96 | 0.07 |
Interleukin-6 (pg/ml) | − 138.51 ± 55.55 | − 150.41 ± 45.73 | − 19.13 ± 68.31 | 0.015 |
TNF alpha (pg/ml) | − 23.15 ± 10.95 | − 18.67 ± 8.92 | − 6.12 ± 9.43 | 0.034 |
IFN-gamma (pg/ml) | − 82.5 ± 69.34 | − 143.73 ± 53.72 | − 43.94 ± 32.33 | 0.024 |
CRP (mg/L) | − 7.27 ± 5.37 | − 9.83 ± 7.47 | − 2.26 ± 0.94 | 0.041 |