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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Xeno-free generation of human induced pluripotent stem cells from donor-matched fibroblasts isolated from dermal and oral tissues

Fig. 6

Relative gene expression of the A–C mesoderm, D endoderm and E, F ectoderm markers by the iPS following directed differentiation toward the three lineages. G Heatmap analysis of the gene expression of trilineage markers by the iPS before and after directed (induced) differentiation. Expression is presented relative to the uninduced DF-iPS-FBS group ± SD (uninduced iPS not shown on graphs). Independent samples t-test and one-way ANOVA were used to determine statistical significance (p < 0.05). (*) represents significance between the induced iPS, from the same source, grown in FBS to those grown in PL. ( +) represents significance between the induced iPS-FBS. (#) represents significance between the induced iPS-PL (DF: dermal fibroblasts, BF: buccal fibroblasts, GF: gingival fibroblasts, iPS: induced pluripotent stem cells, FBS: fetal bovine serum, PL: platelet lysate, ENDO: endoderm, MESO: mesoderm, ECTO: ectoderm)

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Stem Cell Research & Therapy

ISSN: 1757-6512