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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Machine learning-identified stemness features and constructed stemness-related subtype with prognosis, chemotherapy, and immunotherapy responses for non-small cell lung cancer patients

Fig. 7

Interference with ARTN inhibits the proliferation, migration, invasion and stemness of lung cancer cells. A K–M analysis shows that patients with high ARTN expression have a worse prognosis. B qRT-PCR results demonstrate the difference in transcript levels of ARTN in normal lung epithelial cells (HBE) and lung cancer cells (NCIH1299, PC9, NCIH292, NCIH460). C qRT-PCR results demonstrating the differences in transcript levels of ARTN in clinically paired tissue samples. D Differential protein expression of ARTN in clinical paired tissue samples detected by immunohistochemistry. E qRT-PCR to detect the interference effect of ARTN-siRNAs. F Lung cancer cell growth after ARTN-siRNAs interference. (G) Clonal colony formation after ARTN-siRNAs interference. H Invasion and migration of lung cancer cells after ARTN-siRNAs interference. I Stem cell formation in lung cancer cells after ARTN-siRNAs interference. J Changes in transcript levels of stem Markers (SOX2, CD44, NANOG, POU5F1, CD133, C-myc, KLF4) after ARTN-siRNAs interference

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Stem Cell Research & Therapy

ISSN: 1757-6512