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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Dendritic cells mediated by small extracellular vesicles derived from MSCs attenuated the ILC2 activity via PGE2 in patients with allergic rhinitis

Fig. 2

MSC-sEVs inhibited the effects of dendritic cells on ILC2s in patients with allergic rhinitis. A. Schematic representation of mDCs and sEV-mDCs generation and co-cultures. B–F. PBMCs from patients with AR were co-cultured with allogeneic mDCs or sEV-mDCs for 3 days. B. The levels of IL-13 in the supernatants were analyzed by ELISA (n = 8). C. Gating strategy of human ILC2s with Lin−CRTH2+CD127+. D-E. Intracellular IL-13 levels in ILC2s were analyzed by flow cytometry (n = 10). F-G. Levels of GATA3 in ILC2s were analyzed by flow cytometry (n = 4). DC: dendritic cell; ILC2: group 2 innate lymphoid cell; MSC: mesenchymal stromal cell; sEV: small extracellular vesicle. Data are shown as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001

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Stem Cell Research & Therapy

ISSN: 1757-6512