Fig. 5

The expression of PGE2 and IL-10 in sEV-mDCs and mDCs. A–B. GO analysis and KEGG enrichment analysis of differential mRNAs between mDCs and sEV-mDCs. C. Heatmap representation of differential mRNAs involved in ILC2s regulation between mDCs and sEV-mDCs. D. The violin plot showed the differential expression of PTGES, IL10 and TNFSF15 in mDCs and sEV-mDCs. E. The levels of PTGES, IL10 and TNFSF15 were examined by RT-quantitative PCR (n = 6–18). F. The levels of PGE2 in the supernatants of mDCs and sEV-mDCs (n = 16). G-H. The levels of IL-10 in the supernatants of mDCs and sEV-mDCs and co-cultured PBMCs (n = 13–16). PTGES: Prostaglandin E Synthase; IL-10: Interleukin-10; PGE2: Prostaglandin E2. Data are shown as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001