Fig. 3

Functional analysis of proteins that showed significant change in the typical GR or PR. A, B 173 proteins that were significantly increased after the third injection compared to that at the baseline in the typical GR were analyzed. A The functional annotation classified in biological processes. B Activated canonical pathway after the third injection. C, D 45 proteins that were significantly increased after the third injection compared to that at baseline in the typical PR were analyzed. C The functional annotation classified in biological process. D Activated and inactivated canonical pathway after the third injection. Each gene ontology was considered to be significant when FDR q < 0.05. The canonical pathway was considered to be significant when − log (p-value) ≥ 2.0 and activation Z-score ≥ 2.0 or activation Z-score ≤  − 2.0. FDR False Discovery Rate; GR Good Responder; PR Poor Responder