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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Menstrual blood-derived mesenchymal stromal cells: impact of preconditioning on the cargo of extracellular vesicles as potential therapeutics

Fig. 4

Changes in tetraspanins, EV biogenesis, and MSC markers in EV samples upon different preconditioning of MenSCs. A Abundance levels of the tetraspanins CD9, CD63, and CD81 (upper panel) and other EV biogenesis molecules like TSG101, FLOT1, and ALIX (lower panel) were individually evaluated among different EV groups. B The most representative MSC markers were also analyzed. Box plots indicate median protein abundance level based on MaxLFQ values in B-EVs (red), PI-EVs (green), PHY-EVs (blue), and AH-EVs (yellow) samples. Significant differences were tested by ANOVA one-way (Tukey´s post hoc test vs. basal conditions). *, p < 0.05; **, p < 0.005; and ***, p < 0.0005. EVs, extracellular vesicles; MenSCs, menstrual blood-derived stromal cells; B-EVs, EVs released by basal MenSCs; PI-EVs, EVs released by pro-inflammatory primed MenSCs; PHY-EVs, EVs released by physioxia cultured MenSCs; AH-EVs, EVs released by acute hypoxia cultured MenSCs

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Stem Cell Research & Therapy

ISSN: 1757-6512