Fig. 6

Liver macrophage exhaustion or PPARγ inhibition abolished the therapeutic effect of hUCMSCs on DLC. A Outline of the experimental procedure for hUCMSCs treatment in normal and macrophage-depleted DLC rats. B The ratio of the liver weight to the body weight for rats (NC and DLC group, n = 5; hUCMSC group, n = 4). C Representative sections of livers stained with H&E from six groups after different treatments (Bar = 100 μm). D Serum biochemical levels of ALT, AST, ALP, ALB, TBIL, and CREA (NC and DLC group, n = 5; DLC + hUCMSCs and DLC-Lip(C) group, n = 4; DLC-Lip and DLC-Lip + hUCMSCs group, n = 3). E Examination of serum PT levels (NC and DLC group, n = 5; DLC + hUCMSCs and DLC-Lip(C) group, n = 4; DLC-Lip and DLC-Lip + hUCMSCs group, n = 3). F ALB levels were measured after PPARγ inhibition (NC group, n = 6, DLC group, n = 5; hUCMSCs and hUCMSCs + GW9662 group, n = 6). Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 and ns (no statistical significance) (all p values were obtained by Two-tailed Student’s Test)