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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: hESC-derived striatal progenitors grafted into a Huntington’s disease rat model support long-term functional motor recovery by differentiating, self-organizing and connecting into the lesioned striatum

Fig. 6

Long-term transplantation and enriched environment improve motor behavior with no effect on muscular trophism. A The graft alone improves complex motor performance as examined in the rotarod test compared to animals that were lesioned but did not receive the graft (SHAM) (two-way ANOVA, SHAM SE vs. TRP SE, Group: F(1;96) = 58.48; p < 0.001). Data are normalized over ‘lesion’ values and represented as mean ± SEM. Asterisks indicate the main effects of the groups. See Additional file 1: Table S1 for post hoc analysis. B Exposure to EE improves motor recovery in SHAM rats, outperforms TRP SE condition and it equals the motor rescue obtained in EE grafted animals (two-way ANOVA, Group: F(3;208) = 39.93; p < 0.001). 6MPT data normalized over “lesion” values are plotted. Data are represented as mean ± SEM. Asterisks indicate the main effects of the groups. See Additional file 1: Table S1 for additional information. N = 7 SHAM SE; 7 SHAM EE; 7 TRP SE; 9 TRP EE. C and D Measurements of muscle fiber area of contralesional gastrocnemius (C) and triceps (D) in the examined experimental groups and conditions (one way ANOVA, p > 0.05 ns); N = 3 SHAM SE; 3 SHAM EE; 3 TRP SE; 3 TRP EE. Data are represented as mean ± SEM

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Stem Cell Research & Therapy

ISSN: 1757-6512