Fig. 7
From: hUC-MSC transplantation therapy effects on lupus-prone MRL/lpr mice at early disease stages
hUC-MSC transplantation improved renal damage in 14-week-old MRL/lpr mice. A Pathological staining. Glomerular inflammatory cell infiltration significantly reduced, and glomerular fibrosis significantly improved in MSC transplanted mice compared to the Ctrl. Scale bar: 50 μm and 25 μm, respectively. B Immunofluorescence assay. IgG and IgM antibody deposition in the kidneys of MSC transplanted mice were significantly lower than in the Ctrl group. Scale bar: 25 μm. C Statistical diagram of H&E staining (a), MASSON staining (b), C3 immunofluorescence staining (c), IgM immunofluorescence staining (d), and IgG immunofluorescence staining (e). (Ctrl: control, LD: low dose, MD: middle dose, HD: high dose). The number of mice is n = 5