Fig. 4

Physiological performance after deletion of NG2⁺ PCs. PC-deletion induced by Tam treatment of NG2-CreERT/Rosa-DTA mice. Rosa-DTA mice with Tam or NG2-CreERT/DTA without Tam were used as control A and B (Ct A, Ct B), respectively. After primary Tam treatment at the start point, mice were treated with Tam every month. A The time course of body weight of PC-deletion (PC-del) and control mice. B At 4 months after PC deletion, exercise tolerance was assessed using the treadmill test. C At indicated time after induction of PC-deletion, muscular power was estimated by the grip strength of four limbs. The value was normalized by body weight, and presented as the means ± SEM (n = 4–8); *P < 0.05, ns = not significant