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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Single-cell RNA sequencing of human non-hematopoietic bone marrow cells reveals a unique set of inter-species conserved biomarkers for native mesenchymal stromal cells

Fig. 3

Key molecular factors specific to BM-MSCs. A Protein–protein interaction (PPI) network study revealed key factors that were the most connected to the others. Analysis performed with Cytoscape. B Venn diagram showing the number and the name of DEGs between human BM-MSCs analyzed above and mouse BM-MSCs previously described [26, 27, 29, 30]. Heatmap panel: distribution of pro-hematopoietic interspecies markers visualized in matrix plot among human non-hematopoietic subsets and mice identified above (size of dots are related to the percentage of positive cells and colors to gene normalized expression according to the color scale). Lower panel: expression of the interspecies (human and mouse) markers (CFD, CXCL12, PDGFRA) among non-hematopoietic human subsets in UMAP plots described above and quantified in violin plots labeling significantly MSCs (p < 0.05)

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Stem Cell Research & Therapy

ISSN: 1757-6512