Combination of adipose-derived stem cell conditioned media and minoxidil for hair regrowth in male androgenetic alopecia: a randomized, double-blind clinical trial

Legiawati, Lili; Suseno, Lis Surachmiati; Sitohang, Irma Bernadette S.; Yusharyahya, Shannaz Nadia; Pawitan, Jeanne Adiwinata; Liem, Isabella Kurnia; Kurniawati, Trie; Ardelia, Athaya; Paramastri, Kanya

doi:10.1186/s13287-023-03440-2

Stem Cell Research & Therapy

Table 3 Changes from baseline to week 6 using trichoscan examination

From: Combination of adipose-derived stem cell conditioned media and minoxidil for hair regrowth in male androgenetic alopecia: a randomized, double-blind clinical trial

	Observed value						Changes from baseline
	Placebo			Intervention			Placebo	Intervention	p^b
	Week 0	Week 6	p^a	Week 0	Week 6	p^a	Placebo	Intervention	p^b
Non-concentrated ADSC-CM (n = 17)
HC	164.76 ± 57.76	321.47 ± 120.09	0.006	132.29 ± 68.86	317.17 ± 118.89	0.000	156.70 ± 59.79	184.88 ± 119.63	0.563
HD	182.73 ± 64.35	352.71 ± 117.14	0.001	137.99 ± 68.47	351.11 ± 131.62	0.000	169.97 ± 158.95	213.12 ± 146.57	0.417
VR	36.71 ± 20.92	22.04 ± 12.98	0.003	43.05 ± 19.84	18.54 ± 11.76	0.001	− 14.67 ± 15.81	− 24.51 ± 22.53	0.150
TR	63.28 ± 20.92	77.95 ± 12.98	0.003	57.23 ± 19.48	81.42 ± 11.75	0.001	14.67 ± 15.81	24.19 ± 22.21	0.160
MT	0.041 ± 0.00	0.056 ± 0.01	0.000	0.042 ± 0.08	0.062 ± 0.01	0.004	0.016 ± 0.01	0.024 ± 0.01	0.120
TFU	115.29 ± 28.56	90.29 ± 35.32	0.005	178.23 ± 37.38	176.29 ± 41.74	0.847	− 25.00 ± 31.21	− 1.94 ± 40.86	0.220
Concentrated ADSC-CM (n = 20)
HC	125.65 ± 39.19	310.10 ± 104.70	0.000	130.50 ± 45.86	310.15 ± 104.70	0.000	184.45 ± 103.92	174.65 ± 119.89	0.784
HD	138.61 ± 42.74	343.30 ± 115.91	0.000	144.47 ± 50.78	337.82 ± 16.58	0.000	204.69 ± 14.45	193.34 ± 132.73	0.774
VR	43.69 ± 18.23	16.52 ± 7.66	0.000	38.66 ± 19.20	15.35 ± 7.75	0.000	− 27.16 ± 18.94	− 23.31 ± 20.16	0.568
TR	56.61 ± 18.22	83.47 ± 7.66	0.000	61.33 ± 19.20	84.65 ± 7.75	0.000	26.86 ± 18.81	23.32 ± 20.15	0.569
MT	0.045 ± 0.01	0.069 ± 0.13	0.000	0.046 ± 0.01	0.074 ± 0.01	0.000	0.024 ± 0.01	0.027 ± 0.01	0.577
TFU	93.00 ± 23.10	171.85 ± 35.79	0.000	94.95 ± 21.74	174.60 ± 38.57	0.000	78.85 ± 41.63	79.65 ± 46.34	0.955

Bold values indicate statistical significance
HC Hair count, HD Hair density, VR Vellus rate, TR Terminal rate, MT Mean thickness, TFU Total follicular units
^ap values according to paired samples T-Test or Wilcoxon’s signed-rank test
^bp values according to independent-samples T-test

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