Integrated modeling framework reveals co-regulation of transcription factors, miRNAs and lncRNAs on cardiac developmental dynamics

Table 2 Heart target genes of cardiac TFs during hESC/hiPSC-CM differentiation

TF	Number of TF-target genes at early stage				Number of TF-target genes at late stage
TF	H7-ESC-CM	hiPSC-CM (GSE81585)	hiPSC-CM (GSE35671)	Conserved target	H7-ESC-CM	hiPSC-CM (GSE81585)	hiPSC-CM (GSE35671)	Conserved target
GATA4	51	52	33	28	54	38	14	31
GATA6	120	120	114	71	198	99	30	90
HAND1	91	75	40	46	110	54	9	53
HAND2	101	77	31	59	138	62	51	58
HEY2	130	120	78	85	111	55	26	51
IRX4	20	9	5	11	35	4	6	8
ISL1	25	22	12	16	19	12	12	10
MEF2A	67	67	63	42	89	61	39	51
MEF2C	39	40	4	26	29	37	13	12
MESP1	188	176	100	103	162	82	45	86
NKX2-5	83	50	25	39	56	62	24	34
NR2F2	94	89	47	58	27	124	44	16
SRF	85	94	78	36	121	74	66	66
TBX5	95	61	43	54	111	84	44	64

The “conserved target” is the target genes that are regulated by at least one common TF, and are detected by H7-ESC dataset and at least one of two hiPSC datasets (GSE81585 and GSE35671)

ISSN: 1757-6512