Integrated modeling framework reveals co-regulation of transcription factors, miRNAs and lncRNAs on cardiac developmental dynamics

Table 3 Heart target genes co-regulated by ncRNAs (miRNAs and lncRNAs) and cardiac TFs during hESC/hiPSC-CM differentiation

ncRNAs	Number of heart target genes (early stage)				ncRNAs	Number of heart target genes (late stage)
ncRNAs	H7-CMs	hiPSC-CMs (GSE81585)	hiPSC-CMs (GSE35671)	Conserved targets	ncRNAs	H7-CMs	hiPSC-CMs (GSE81585)	hiPSC-CMs (GSE35671)	Conserved targets
miR-1	57	56	59	27	let-7i	74	22	15	12
miR-133a	39	67	51	20	miR-1	55	29	28	14
miR-199a	41	57	30	17	miR-133a	51	34	24	10
miR-208	40	39	49	15	miR-15	95	33	33	14
miR-23	81	75	50	29	miR-199a	61	21	23	10
miR-499a	39	56	46	17	miR-200c	90	43	26	17
miR-590	60	57	34	17	miR-29a	46	26	29	15
					miR-31	42	35	23	11
					miR-34a	61	39	35	19
					miR-499a	76	39	17	12
GAS5	43	55	64	18	GAS5	67	57	17	9
H19	42	47	63	16	H19	47	63	8	12
MALAT1	60	107	38	24	MALAT1	83	32	38	26
MEG3	30	123	40	14	MEG3	94	19	8	9
MIAT	19	48	20	2	MIAT	69	43	18	5
NEAT1	82	94	85	40	NEAT1	101	39	63	40
PVT1	49	62	23	17	PVT1	52	14	11	6
TUG1	40	60	30	14	TUG1	69	68	10	8
XIST	27	50	17	8	XIST	51	26	3	2

The “conserved target” is the target genes that are regulated by at least one common miRNA or lncRNA, and are detected by H7-ESC dataset and at least one of two hiPSC datasets (GSE81585 and GSE35671)

ISSN: 1757-6512