Table 4 Specific pathways and biological processes co-regulated by TF-lncRNA-miRNA during development of embryo-derived arial and ventricular cardiomyocytes
Processes/pathway | Embryo-CMs | Main regulatory factors | ||
|---|---|---|---|---|
TF | miRNA | lncRNA | ||
Apoptosis | CM-AE | GATA6, HEY2 | miR-199a, -590 | GAS5, PVT1, MEG3 |
CM-VE | HEY2, NR2F2, TBX5, HAND1 | miR-499a, -133a | GAS5, MALAT1 | |
CM-AL | SRF, TBX5, NR2F2 | miR-200c | MALAT1, PVT1, XIST, MEG3 | |
CM-VL | SRF, NR2F2, HEY2 | miR-499a, -133a | MALAT1 | |
Cell cycle | CM-AE | HEY2, GATA6 | miR-499a, -133a, -590 | PVT1, GAS5 |
CM-VE | NR2F2, MESP1 | miR-199a, -499a, -590 | GAS5, H19 | |
CM-AL | HEY2, HAND1, SRF, NKX2-5, TBX5, NR2F2 | miR-200c, -199a | ||
CM-VL | MESP1, SRF, NR2F2 | miR-199a, -499a, -133a | MIAT, MALAT1 | |
Cell proliferation | CM-AE | GATA6, SRF | miR-590, -23, -199a | MALAT1 |
CM-VE | NR2F2, HAND1 | miR-590, -133a | GAS5, MALAT1 | |
CM-AL | TBX5, GATA6 | miR-200c, -1 | PVT1, MALAT1 | |
Transmembrane transport | CM-VL | GATA6, NR2F2 | miR-1 | MALAT1 |