Fig. 4
From: Efficient delivery of mesenchymal stem/stromal cells to injured liver by surface PEGylation
Inhibition of lung entrapment and improvement of homing efficiency of MSCs by PEG modification. A Tissue distribution of intravenously injected unmodified and PEG20k-C3H10T1/2 cells in normal mice. Unmodified or PEG20k-C3H10T1/2/Nluc cells were injected into the tail vein of C3H/He mice. One hour after injection, the organs and blood were collected, and the luciferase activity was measured. The error bars represent ± SD, n = 3, *p < 0.05 versus unmodified group. B Typical images of lung tissue section. Frozen lung sections were observed 1 h after injection of CFSE-labeled unmodified or PEG20k-C3H10T1/2 cells (scale bars: 100 μm). C, D Homing of m17.ASC cells to injured liver in CCl4-induced acute liver failure model mice. C Schematic image of experimental design. Schematic created with Microsoft PowerPoint. D The luciferase activity in the liver was measured 24 h after intravenous injection of unmodified or PEG20k-m17.ASC/Nluc cells to normal or CCl4-injured FVB mice. The error bars represent ± SD, n = 4, *p < 0.05 versus unmodified group