Fig. 5
From: Efficient delivery of mesenchymal stem/stromal cells to injured liver by surface PEGylation
Therapeutic effect of PEG-MSCs in CCl4-induced acute liver failure model mice. A Schematic image of the experimental design. Schematic created with Microsoft PowerPoint. B Serum AST and ALT levels of acute liver failure model mice treated with PEG-m17.ASC cells. The serum AST and ALT levels were measured 48 h and 96 h after CCl4 injection (42 h and 90 h after m17.ASC injection). The normal mice group was administered neither CCl4 nor m17.ASC cells. The CCl4-injured mice group was administered only CCl4. The error bars represent ± SD, n = 4–14, *p < 0.05, **p < 0.01, ***p < 0.001 versus CCl4-injured mice group. C, D Anti-inflammatory effect of PEG20k-m17.ASC cells. Ninety six hours after CCl4 injection (90 h after m17.ASC injection), the liver section was stained with hematoxylin and eosin (C). Furthermore, the inflammation area accompanying the leucocyte infiltration was measured by ROI analysis (D). The normal mice group was administered neither CCl4 nor m17.ASC cells. The CCl4-injured mice group was administered only CCl4. The error bars represent ± SD, n = 4, *p < 0.05 versus CCl4-injured mice group (scale bars: 100 μm. N.D. not detected)