Fig. 1

hESC-exo alleviate BLM-induced lung inflammation. A. Schema of the experimental procedure. B. Mouse body weight changes over the experimental period. C. Comparison of lung weights across the three groups of mice. D-G. hESC-exo treatment improved respiratory rate (D), tidal volume (E), ventilatory volume per minute (F), and airway resistance (G). H. Lung morphological changes in the three groups. I. Representative lung sections stained with hematoxylin and eosin (H and E). J. Total protein concentration changes in BALF from the three groups of mice. K–M. The levels of IL-6 (K), IL-1β (L), and IL-17A (M) in BALF from the different groups of mice as determined by ELISA. N-P. qPCR analysis of mRNA levels of the pulmonary inflammatory genes, IL-6 (N), IL-1β (O), and IL-17A (P), in the three groups. Scale bar: 200 μm; n = 3–6; mean ± se; *P < 0.05, **P < 0.01, and ***P < 0.001