Fig. 2

hESC-exo alleviate BLM-induced lung fibrosis in mice. A. Schematic of the BLM mouse model preparation and hESC-exo administration procedures. B. Mouse body weight changes over the experimental period. C. Survival of mice treated with or without hESC-exo throughout the experiment. D. Representative CT scan images. The images clearly show that hESC-exo treatment significantly improved BLM-induced lung fibrosis. E–F. Thermal imaging of pulmonary arterial flow changes. The results showed that BLM treatment resulted in a significant reduction in pulmonary blood flow, which partially recovered after hESC-exo treatment. G-J. Detection of lung function changes: respiratory frequency (G), tidal volume (H), ventilation per minute (I), and airway resistance (J). Scale bar: 200 μm; n = 3–15; mean ± se; *P < 0.05, **P < 0.01, and ***P < 0.001