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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Exosomal miR-17-5p from human embryonic stem cells prevents pulmonary fibrosis by targeting thrombospondin-2

Fig. 6

The mechanism of hESC-exo protects against BLM-induced pulmonary fibrosis. miR-17-5p was delivered by hESC-exo into recipient cells like AECs to regulate the mRNA transcription of Thbs2 in nucleus, resulting in the decreased translation of Thbs2 in the cytoplasm. Downstream fibrosis-related proteins like α-SMA, Fn, and Collagen I were downregulated due to the inhibited Thbs2, subsequently

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Stem Cell Research & Therapy

ISSN: 1757-6512