Fig. 1

Schematic representation of the Piezo1 channel. a Bottom view; b top view; c, d lateral view. In response to mechanical stimulation, these arms bend, resulting in localized deformation of the cell membrane and opening of the channel. The cations then flow into the cytoplasm through Piezo channels, and the cells become activated, resulting in the corresponding biological effects. CED: C-terminal extracellular domain; CTD: intracellular C-terminal domain; IH: inner helix; OH: outer helix; PHs: peripheral helices. The figure was created for this article, and the image depicted in this figure is ours; it is not based on any previously published image