Table 1 The characteristics of Piezo1 and Piezo2

Structure

A homotrimeric structure resembling a three-bladed propeller

[8, 11, 16]

Conducting cations

Selective

Nonselective

[4, 8]

Tissue distribution

Skin, bladder, lung, kidney, endothelial cells, periodontal ligament cells, erythrocytes, trigeminal sensory neurons, dorsal root ganglion

Trigeminal sensory neurons, dorsal root ganglion, Merkel cells, and somatic neuron cells

[7,8,9,10,11,12]

Function

Involved in mechanotransduction in a variety of cells

Senses slight touch and proprioception

[8,9,10, 13, 15, 17,18,19,20]

Activator

Yoda1, Jedi1/2

Not found yet

[8, 21, 22]

Inhibitor

Ruthenium red, gadolinium, streptomycin, and GsMTx4

Ruthenium red, gadolinium, streptomycin, GsMTx4, and FM1-43

[4, 7, 8, 23,24,25]