From: The functional effects of Piezo channels in mesenchymal stem cells
Ion channel | Cell/tissue | External stimulation | Signaling pathway | Functional effect | References |
---|---|---|---|---|---|
Piezo1 | BMSCs | HP | Piezo1- ERK1/2, p38 MAPK- BMP2 | Promote osteogenesis and inhibit adipogenesis in BMSCs | [28] |
Piezo1 | BMSCs | Viscoelasticity of hydrogels | - | Regulate the differentiation of BMSCs from osteogenesis to adipogenesis | [29] |
Piezo1 | BMSCs | Triboelectric stimulation | Piezo1-Ca2+-HIF-1α-EDN1, VEGFA | Restore the vitality of aging BMSCs and enhance osteogenesis and proangiogenic functions | [30] |
Piezo1 | MSCs | Antibody of Piezo1 | - | Enhance osteogenesis in MSCs | [36] |
Piezo1/2 | BMSCs | Nanovibrational stimulation | - | Enhance three-dimensional osteogenesis in BMSCs | [37] |
Piezo1/2 | BMSCs | Nanovibrational stimulation | Piezo1/2-ERK1 | Enhance the osteogenic differentiation of BMSCs | [35] |
Piezo1/2 | BMSCs, ADSCs, UCSCs | Megahertz-order nanomechanostimulation | Piezo1/2-RhoA | Enhance the osteogenic differentiation of MSCs | [89] |
Piezo1 | BMSCs | Nanotopography | Yap-Piezo1 | Enhance osteogenesis in BMSCs | [90] |
Piezo1/2 | BMSCs | Fluid shear stress and ECM stiffness | Piezo1/2-Ca2 + -Pppp3ca-NFATc1, YAP1, Ctnnb1 | Promote osteogenic differentiation and bone formation in BMSCs | [91] |
Piezo1/2 | DPSCs | LIPUS | Piezo1/2-ERK1/2, MAPK | Enhance the proliferation of DPSCs | [59] |
Piezo1 | DPMSCs | Yoda1 | Piezo1-PYK2, MEK/ERK, P2 receptor purinergic signaling | Regulate the migration of DPMSCs | [31] |
Piezo1 | PDLSCs | GsMTx4 | Piezo1-ERK | Suppress key PDLSCs biomarkers | [94] |
Piezo1 | PDLSCs | LIPUS | – | Promote endothelial differentiation and angiogenesis in PDLSCs | [32] |
Piezo1 | PDLSCs | Compressive stress | Piezo1-NF-kB | Enhance the ability of PDLSCs to induce osteoclastogenesis | [33] |
Piezo1 | PDLSCs | Stretch stress | Piezo1-Notch1 | Enhance osteogenic differentiation in PDLSCs | [95] |
Piezo1 | SHEDs | HP | Piezo1-Wnt/β-catenin | Enhance osteogenesis and odontogenesis in SHEDs | [96] |
Piezo1 | DFSCs | Yoda1 | Piezo1-Wnt/β-catenin | Promote the proliferation and osteogenic differentiation of DFCs | [104] |
Piezo1 | ADSCs | Swelling of microgels | Piezo1-Ca2+-MAPK | Promote the differentiation of ADSCs into nucleus pulposus-like cells | [105] |
Piezo1/2 | ADSCs | LIPUS | Piezo1/2-ERK- VEGF | Promote the proliferation and cell cycle progression of ADSCs | [34] |
Piezo1 | UCMSCs | Stiffness | Piezo1-Ca2+- | Promote the differentiation of UCMSCs into cardiomyocytes in a low stiffness matrix | [106] |
Piezo1 | EMSCs | Yoda1 | Piezo1-Ca2+- | Inhibit the migration and proliferation of EMSCs | [107] |