The functional effects of Piezo channels in mesenchymal stem cells

Table 3 The functional effects and signaling pathways of Piezo channels in MSCs

Functional effect	Signaling pathway	Ion channel	References
+ Proliferation	Piezo1/2-ERK1/2, MAPK;	Piezo1/2	[34, 59, 104]
	Piezo1-Wnt/β-catenin;
	Piezo1/2-ERK- VEGF
− Proliferation	Piezo1-Ca²⁺	Piezo1	[107]
+ Osteogenesis	Piezo1- ERK1/2, p38 MAPK- BMP2;	Piezo1/2	[28, 30]
	Piezo1-Ca²⁺-HIF-1α-EDN1, VEGFA;		[36, 37]
	Piezo1/2-ERK1;		[35, 89]
	Piezo1/2-RhoA;		[90, 91]
	Yap-Piezo1;		[95, 96]
	Piezo1/2-Ca²⁺-Pppp3ca-NFATc1, YAP1,		[104]
	Ctnnb1;
	Piezo1-Notch1;
	Piezo1-Wnt/β-catenin;
+ Adipogenesis	–	Piezo1	[29]
− Adipogenesis	Piezo1- ERK1/2, p38 MAPK- BMP2;	Piezo1	[28]
+ Migration	Piezo1-PYK2, MEK/ERK, P2 receptor purinergic signaling	Piezo1	[31]
− Migration	Piezo1-Ca²⁺-	Piezo1	[107]
+ Angiogenesis	Piezo1-Ca²⁺-HIF-1α-EDN1, VEGFA	Piezo1	[30, 32]
+ Osteoclastogenesis	Piezo1-NF-kB	Piezo1	[33]
+ Odontogenesis	Piezo1-Wnt/β-catenin	Piezo1	[96]
+ NP-like cells	Piezo1-Ca²⁺-MAPK	Piezo1	[105]
+ Restore vitality	Piezo1-Ca²⁺-HIF-1α-EDN1, VEGFA	Piezo1	[30]

ISSN: 1757-6512