Fig. 6
From: The characteristics and medical applications of antler stem cells
Effects of ASCs on liver fibrosis in rats treated with CCI4. A Compared with intact mice, the CCl4 + PBS control group showed increased liver volume and visible nodules on the surface. The CCl4 + ASC-treated group showed smaller liver volume and bright red, smooth surface compared with the CCl4 + PBS-treated group. Masson staining showed that the CCl4 + ASC-treated group had significantly lower collagen fibers compared with the control group. Immunohistochemical staining showed that α-SMA+ and TGF-β+ cells were significantly lower in the CCl4 + ASC treatment group. B Immunofluorescence showed that TGF-β expression was significantly decreased in HSCs co-cultured with ASCs. Reproduced with permission from [96]. © 2019 Xiaoli Rong et al. ASCs, antler stem cells; MSCs, mesenchymal stem cells; α-SMA, anti-α smooth muscle actin; TGF-β, transforming growth factor-β; HSC, hepatic stellate cells; CCl4, carbon tetrachloride; SFM, serum-free medium; PBS, phosphate-buffered saline