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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Photo-click hydrogels for 3D in situ differentiation of pancreatic progenitors from induced pluripotent stem cells

Fig. 5

Emergence of extraembryonic cells in 3D hydrogels following PP differentiation. a Volcano plot showing enrichment of genes within cluster 2. b Feature plot of cluster 2 showing cells with MMP9 upregulation. c Bubble plots of enriched gene sets within cluster 2 in 3D relative to the 2D control. d Representative immunostaining images of TFAP2A-positive extraembryonic cells at each stage of differentiation in 3D GelNB hydrogels. At least 3 regions of interest were imaged (10 slices in each z-stack with a slice height of 10 µm)

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Stem Cell Research & Therapy

ISSN: 1757-6512