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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Complex deformation of cartilage micropellets following mechanical stimulation promotes chondrocyte gene expression

Fig. 5

Mechanical stimulations of cartilage micropellets with a square pressure signal specifically upregulated the expression of articular chondrocyte markers. Micropellets of 21 days were stimulated by a square-wave pressure with an amplitude of 3.5 kPa and a frequency of 1 Hz for 30 min. Fold change expression of genes for articular chondrocytes (SOX9, AGG, COL IIB and LINK), hypertrophic chondrocytes (COL X, MMP13, ADAMTS5), fibrochondrocytes (COL I) and osteoblasts (RUNX2, SPARC and AP) were analyzed 3 h after stimulations and compared to non-stimulated control (NS) (n = 15 groups of 6 micropellets)

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Stem Cell Research & Therapy

ISSN: 1757-6512