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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Single-cell sequencing reveals the existence of fetal vascular endothelial stem cell-like cells in mouse liver

Fig. 3

Trajectory analysis reveals stem cell-like populations in perinatal micro- and macrovascular ECs. a UMAP visualization of ECs from this study and published data [10]. b Trajectory analysis of ECs from E12 until W8 projected onto the UMAP plot. c UMAP embedding of PV EC clusters colored and labeled by cell type. d Dot plot of known endothelial stem cell or progenitor marker expression in PV EC clusters. e Comparison of GO biological process enrichment in each cluster. f RNA velocity from E14 through P14 illustrating development of fetal VESCs at E14 and transition from fetal VESCs to adult VESCs at P7. g Model of EC development in the portal vein and hepatic artery. Arrows indicate the possible differentiating and reprogramming directions

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Stem Cell Research & Therapy

ISSN: 1757-6512