Fig. 4

AT transplantation impact on systemic metabolic homeostasis in Seipin KO mice. A Representative CT scan images from coronal and transverse views from each group. B Representative gross appearance of subcutaneous AT. C CT scan showing the weight of surviving AT four months after AT transplantation (n = 5). **p < 0.01 vs. KO-Sham. D AT sections stained with HE to show the morphology of transplanted AT. Scale bar = 50 μm. E and F The serum adiponectin and leptin levels in the Seipin KO mice after AT transplantation (n = 5). **p < 0.01 vs. WT-Sham, ***p < 0.001 vs. WT-Sham, #p < 0.05 vs. KO-Sham, ##p < 0.01 vs. KO-Sham. G and H The ratio of liver weight to body weight and fasting blood glucose levels in the Seipin KO mice after AT transplantation (n = 5). **p < 0.01 vs. WT-Sham, ##p < 0.01 vs. KO-Sham. I and J Blood glucose levels after AT transplantation in Seipin KO mice with glucose load (I) and insulin injection (J). n = 5, *p < 0.05 vs. WT-Sham, #p < 0.05 vs. KO-Sham. Data were shown as means ± SD