Fig. 3From: The spatiotemporal heterogeneity of the biophysical microenvironment during hematopoietic stem cell development: from embryo to adultBiophysical microenvironment of heterogeneous HSC niches. Bone marrow is the primary niche for adult HSC maintenance. When the individual is under severe stress or the BM microenvironment becomes suboptimal due to pathological conditions, extra-medullary hematopoiesis (EMH) can occur, mostly in the liver or spleenBack to article page